[4-(3-Pyridylthiomethyl)-2-phenylbenzoyl]methionine methyl ester → HCID 10647304, compound

HRID 2121205Notes

Reaction equation

HRID 2121205 reaction equation
C[O:2][C:3](=[O:32])[C@H:4]([CH2:28][CH2:29][S:30][CH3:31])[NH:5][C:6](=[O:27])[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][S:14][C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)=[CH:9][C:8]=1[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>CC(=O)OCC>[N:17]1[CH:18]=[CH:19][CH:20]=[C:15]([S:14][CH2:13][C:10]2[CH:11]=[CH:12][C:7]([C:6]([NH:5][C@H:4]([C:3]([OH:32])=[O:2])[CH2:28][CH2:29][S:30][CH3:31])=[O:27])=[C:8]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH:9]=2)[CH:16]=1

Participants

3

Reactant 1

HCID 54197885[4-(3-Pyridylthiomethyl)-2-phenylbenzoyl]methionine methyl ester

Product 1

HCID 10647304HCID 10647304, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The desired compound was prepared by saponification of [4-(3-pyridylthiomethyl)-2-phenylbenzoyl]methionine methyl ester, prepared as in Example 236 using the procedure of Example 159. 1H nmr (300 MHz., DMSO-d6): δ 8.54, m, 1H; 8.39, dd, 1H; 7.83, m, 2H; 7.29-7.47, m, 8H; 4.39, s, 2H; 4.24, m, 1H; 2.25, m, 2H; 1.98, s, 3H; 1.85, m, 2H. MS (CI NH3): 453 (MH+); 304, 194. EA: calc'd for C24H24N2O3S2: C, 63.69; H, 5.34; N, 6.19; found C, 63.35; H, 5.20; N, 6.02.

Sources & evidence

ORD record
ord-63f3061f9ca74f5ca6660a514fa4df48
Source dataset
uspto-grants-2004_02
Patent number
US06693123B2

Reaction notes

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