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HRID2121262

反应详情

EQUATION

反应方程式

HRID 2121262 的结构方程式

REACTANTS

反应物

4
结构：CCN=C=NCCCN(C)C
HCID15908

1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide

C8H17N3

结构：COC(=O)[C@@H](N)CC(C)C
HCID65105

(S)-2-Amino-4-methylpentanoic acid methyl ester

C7H15NO2

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：Cc1ccccc1-c1cc([N+](=O)[O-])ccc1C(=O)O
HCID23436074

2'-Methyl-5-nitro[1,1'-biphenyl]-2-carboxylic acid

C14H11NO4

PRODUCTS

生成物

1
结构：COC(=O)[C@H](CC(C)C)NC(=O)c1ccc([N+](=O)[O-])cc1-c1ccccc1C
HCID69892638

未命名化合物

收率 99%

PROCEDURE

实验过程

4-nitro-2-(2-tolyl)benzoic acid (1.72 g, 6.7 mmol) was coupled with (L)-leucine methyl ester in the presence of EDCI and HOBT to give the desired compound (2.55 g, 99% yield). 1H NMR (CDCl3) δ 8.29 (d, J=8.7 Hz, 1H), 8.10-8.16 (m, 2H), 7.18-7.42 (m, 4H), 5.76 (d, J=7.6 Hz, 1H), 4.49 (br m, 1H), 3.66 (s, 3H), 2.19 (s, 1H), 2.08 (s, 2H), 1.30-1.39 (m, 1H), 1.02-1.09 (m, 2H), 0.75-0.80 (dd, J=6.7 and 7.1 Hz, 6H).