Dichloromethane → 5-cyclopropyl-1-(4-methoxybenzyl)-4-(piperazin-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine

HRID 212146Notes

Reaction equation

HRID 212146 reaction equation
[CH:1]1([c:4]2[c:5]([N:26]3[CH2:27][CH2:28][N:29]([C:32]([O:33][C:34]([CH3:35])([CH3:36])[CH3:37])=[O:38])[CH2:30][CH2:31]3)[c:6]3[c:7]([n:8][cH:9]2)[n:10]([CH2:17][c:18]2[cH:19][cH:20][c:21]([O:24][CH3:25])[cH:22][cH:23]2)[n:11][c:12]3[C:13]([F:14])([F:15])[F:16])[CH2:2][CH2:3]1.[Cl:46][CH2:47][Cl:48].[F:39][C:40]([F:41])([F:42])[C:43]([OH:44])=[O:45]>>[CH:1]1([c:4]2[c:5]([N:26]3[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]3)[c:6]3[c:7]([n:8][cH:9]2)[n:10]([CH2:17][c:18]2[cH:19][cH:20][c:21]([O:24][CH3:25])[cH:22][cH:23]2)[n:11][c:12]3[C:13]([F:14])([F:15])[F:16])[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 68765568HCID 68765568, compound

Product 1

HCID 687557085-cyclopropyl-1-(4-methoxybenzyl)-4-(piperazin-1-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine

Sources & evidence

ORD record
ord-7d746af3e62d4f68b3b2ebc209366baf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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