Sodium borohydride → HCID 10126062, compound

HRID 2121487Notes

Reaction equation

HRID 2121487 reaction equation
[OH:1][C@H:2]1[C:11](=[O:12])[C:10]2[C:9]([CH2:13][O:14][CH3:15])=[CH:8][N:7]3[C:16]([CH3:20])=[C:17]([CH3:19])[N:18]=[C:6]3[C:5]=2[NH:4][C@@H:3]1[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[BH4-].[Na+]>>[OH:12][C@@H:11]1[C:10]2[C:9]([CH2:13][O:14][CH3:15])=[CH:8][N:7]3[C:16]([CH3:20])=[C:17]([CH3:19])[N:18]=[C:6]3[C:5]=2[NH:4][C@H:3]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[C@H:2]1[OH:1]

Participants

3

Reactant 2

HCID 4311764Sodium borohydrideHCID 69997187HCID 69997187, compound

Product 1

HCID 10126062HCID 10126062, compound

Procedure

0.4 g of (8R, 9R)-8-hydroxy-6-methoxymethyl-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h]-[1,7]naphthyridin-7-one are reacted with sodium borohydride analogously to Example 15. After purification on silica gel (mobile phase: methylene chloride/methanol=100/3), 120 mg of the title compound [Rf=0.44 (methylene chloride/methanol=13/1)] of melting point 202-5° C. (decomp.) are obtained.

Workup

  1. customAfter purification on silica gel (mobile phase: methylene chloride/methanol=100/3), 120 mg of the title compound [Rf=0.44 (methylene chloride/methanol=13/1)] of melting point 202-5° C. (decomp.)
  2. customare obtained

Sources & evidence

ORD record
ord-2819f4f6698949d7ae119dc102af536f
Source dataset
uspto-grants-2004_02
Patent number
US06696461B2

Reaction notes

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