Ethanol → HCID 10309397, compound

HRID 2121489Notes

Reaction equation

HRID 2121489 reaction equation
[OH:1][C@@H:2]1[C:11]2[C:10]([CH2:12][O:13][CH3:14])=[CH:9][N:8]3[C:15]([CH3:19])=[C:16]([CH3:18])[N:17]=[C:7]3[C:6]=2[NH:5][C@H:4]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C@H:3]1[OH:26].[CH2:27](O)[CH3:28]>>[OH:26][C@H:3]1[C@H:2]([O:1][CH2:27][CH3:28])[C:11]2[C:10]([CH2:12][O:13][CH3:14])=[CH:9][N:8]3[C:15]([CH3:19])=[C:16]([CH3:18])[N:17]=[C:7]3[C:6]=2[NH:5][C@@H:4]1[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 702EthanolHCID 10126062HCID 10126062, compound

Product 1

HCID 10309397HCID 10309397, compound

Procedure

Analogously to Example 15, 350 mg of the title compound [Rf=0.45 (methylene chloride/methanol=13/1)] of melting point 184-6° C. (decomp.) are obtained by reaction of (7R,8R,9R)-7,8-dihydroxy-6-methoxymethyl-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine with ethanol and purification on silica gel (mobile phase: methylene chloride/methanol=100/3).

Sources & evidence

ORD record
ord-eea11ea194b54948b58563c5b0b26468
Source dataset
uspto-grants-2004_02
Patent number
US06696461B2

Reaction notes

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