Water → HCID 22034140, compound

HRID 2121591Notes

Reaction equation

HRID 2121591 reaction equation
Cl[C:2]1[C:3]2[N:11]([CH3:12])[CH:10]=[C:9]([C:13]3[C:18]([CH3:19])=[CH:17][C:16]([O:20][CH3:21])=[CH:15][C:14]=3[CH3:22])[C:4]=2[N:5]=[C:6]([CH3:8])[N:7]=1.[NH2:23][CH2:24][CH2:25][NH:26][C:27](=[O:37])[CH2:28][C:29]1[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[CH:31][CH:30]=1.O>CN1C(=O)CCC1>[CH3:36][O:35][C:32]1[CH:31]=[CH:30][C:29]([CH2:28][C:27]([NH:26][CH2:25][CH2:24][NH:23][C:2]2[C:3]3[N:11]([CH3:12])[CH:10]=[C:9]([C:13]4[C:18]([CH3:19])=[CH:17][C:16]([O:20][CH3:21])=[CH:15][C:14]=4[CH3:22])[C:4]=3[N:5]=[C:6]([CH3:8])[N:7]=2)=[O:37])=[CH:34][CH:33]=1

Participants

5

Reactant 3

HCID 962WaterHCID 13028015HCID 13028015, compoundHCID 22034116HCID 22034116, compound

Product 1

HCID 22034140HCID 22034140, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Heat a solution of 4-chloro-7-(4-methoxy-2,6-dimethyl-phenyl)-2,5-dimethyl-5H-pyrrolo[3,2-d]pyrimidine (120 mg, 0.38 mmol) and N-(2-amino-ethyl)-2-(4-methoxy-phenyl)-acetamide (125 mg) in NMP (2 mL) for 14 h at 130° C. Pour into water (5 mL) and extract with EtOAc (2×10 mL). Dry the combined organic extracts over Na2SO4, filter, and concentrate under reduced pressure to obtain the title compound which is used without further purification.

Workup

  1. extractionextract with EtOAc (2×10 mL)
  2. dry with materialDry the combined organic extracts over Na2SO4
  3. filtrationfilter
  4. concentrationconcentrate under reduced pressure

Sources & evidence

ORD record
ord-652bf16565604f94a406c5cd2053b3e3
Source dataset
uspto-grants-2004_02
Patent number
US06696445B2

Reaction notes

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