反应详情

Add palladium hydroxide (2.0 g) to a solution of [2,5-dimethyl-3-(2,4,6-trimethylphenyl)imidazolo[5,4-b]pyridin-7-yl]benzylamine (1.50 g, 4.05 mmol) in acetic acid (10 mL). Hydrogenate the mixture at a pressure of 40 psi for 20 hr. Filter the reaction mixture through celite, evaporate to dryness under reduced pressure, dilute with EtOAc and successively wash with aq. NaHCO3 and aq NaCl. Dry the organic layer over Na2SO4, filter, and concentrate. Purify by flash column chromatography (3% MeoH in CH2Cl2) to obtain the title compound as a white solid.

1. filtrationFilter the reaction mixture through celite
2. customevaporate to dryness under reduced pressure
3. additiondilute with EtOAc
4. washsuccessively wash with aq. NaHCO3 and aq NaCl
5. dry with materialDry the organic layer over Na2SO4
6. filtrationfilter
7. concentrationconcentrate
8. customPurify by flash column chromatography (3% MeoH in CH2Cl2)