反应详情

Treat a solution of N-[2,5-dimethyl-3-(2,4,6-trimethylphenyl)imidazolo[5,4-b]pyridin-7-yl]-2-chloroacetamide (0.91 g, 2.55 mmol) in THF (5 mL) with borane-methyl sulfide complex (0.8 mL, 7.65 mmol). Heat the mixture to reflux for 18 h and quench at ambient temperature with a large excess of MeOH, followed by 6N HCl (5 mL). Re-heat the mixture to reflux for 1 h, then concentrate under reduced pressure to obtain the title compound as a white crystalline solid.

1. temperatureHeat the mixture
2. temperatureto reflux for 18 h
3. customquench at ambient temperature with a large excess of MeOH
4. temperatureRe-heat the mixture to reflux for 1 h
5. concentrationconcentrate under reduced pressure