反应详情

A mixture of 2,5-di(4-pyridyl)-4-methylthiophene-3-carbaldehyde (0.14 g), hydroxylamine hydrochloride (0.04 g), and pyridine (0.04 mL) in MeOH (3 mL) was heated at reflux temperature for 16 hours. After cooling, the volatiles were removed by evaporation. The resulting residue was dissolved in 10% methanolic HCl (5 mL) and the solution was concentrated in vacuo again. The resulting solid was washed with water (50 mL) and CH2CI2 (30 mL) to provide the title compound (0.045 g).

1. temperaturewas heated
2. temperatureat reflux temperature for 16 hours
3. temperatureAfter cooling
4. customthe volatiles were removed by evaporation
5. dissolutionThe resulting residue was dissolved in 10% methanolic HCl (5 mL)
6. concentrationthe solution was concentrated in vacuo again
7. washThe resulting solid was washed with water (50 mL) and CH2CI2 (30 mL)