Hydrochloric Acid → HCID 178514068, compound

HRID 2121744Notes

Reaction equation

HRID 2121744 reaction equation
[F:1][C:2]([F:36])([F:35])[C:3]1[CH:4]=[C:5]([N:9]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([O:27]CC)=[O:26])=[CH:21][CH:20]=3)=[CH:15][C:14]=2[C:30]2[NH:34][N:33]=[N:32][N:31]=2)[C:10]([NH2:12])=[O:11])[CH:6]=[CH:7][CH:8]=1.[OH-].[Na+].Cl>C(O)C>[F:36][C:2]([F:1])([F:35])[C:3]1[CH:4]=[C:5]([N:9]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[CH:20]=[CH:21][C:22]([C:25]([OH:27])=[O:26])=[CH:23][CH:24]=3)=[CH:15][C:14]=2[C:30]2[NH:34][N:33]=[N:32][N:31]=2)[C:10]([NH2:12])=[O:11])[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178468740HCID 178468740, compound

Product 1

HCID 178514068HCID 178514068, compoundYield 90.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 3-trifluoromethylphenyl-4-(4-ethoxycarbonylphenyl)-2-(5-tetrazolyl)phenyl urea (4.5 g, 9 mmol) in 96% ethanol was added sodium hydroxide (4 N, 25 mL). The reaction was heated to reflux for 30 min, then cooled to room temperature and acidified with hydrochloric acid. The precipitate was filtered off to give 3.8 g of the desired material. M.p. 300° C. (dec.).

Workup

  1. temperatureThe reaction was heated
  2. temperatureto reflux for 30 min
  3. filtrationThe precipitate was filtered off

Sources & evidence

ORD record
ord-4f15f70a19c6432eb2b141d2b5e3b43d
Source dataset
uspto-grants-2004_02
Patent number
US06696475B2

Reaction notes

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