Water → 2-Bromo-5-fluoroanisole

In a 250 mL r.b. flask, a solution of 2-bromo-5-fluorophenol (Lancaster: 7.0 mL, 64 mmol, 1.0 equivuiv) in acetone (140 mL) was treated with iodomethane (Aldrich: 4.8 mL, 77 mmol, 1.2 equivuiv), potassium carbonate (8 g), and water (1 mL). The reaction mixture was heated at reflux for 6 h, cooled to rt, clarified with H2O (40 mL), and the bulk of the volatiles was removed under reduced pressure. The reaction mixture was extracted with EtOAc (3×120 mL); the extracts were washed with brine (1×80 mL), combined, dried (K2CO3), filtered, and concentrated to a clear oil. Bulb-to-bulb distillation (60-65° C., 0.7 Torr) afforded 13.22 g (quant) of 2-bromo-5-fluoroanisole as a colorless liquid. Data for 2-bromo-5-fluoroanisole: 1H NMR (400 MHz, CDCl3): 7.46 (dd, J=10.6, 8.7, 1H); 6.64 (dd, J=10.4, 2.8, 1H); 5.58 (dt, J=10.4, 2.4, 1H); 3.88 (s, 3H).

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 6 h
3. customthe bulk of the volatiles was removed under reduced pressure
4. extractionThe reaction mixture was extracted with EtOAc (3×120 mL)
5. washthe extracts were washed with brine (1×80 mL)
6. dry with materialdried (K2CO3)
7. filtrationfiltered
8. concentrationconcentrated to a clear oil
9. distillationBulb-to-bulb distillation (60-65° C., 0.7 Torr)

ORD record

ord-6ddc69577ce94d548675377239b5fe00

Source dataset

uspto-grants-2004_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06696459B1