Hydrochloric Acid → HCID 69702667, compound

HRID 2121871Notes

Reaction equation

HRID 2121871 reaction equation
[OH:1][CH:2]([CH3:20])[CH2:3][CH2:4][C:5]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:6]=1[NH:13]C(=O)C(C)(C)C.C(O)C.[ClH:24]>O>[Cl-:24].[OH:1][C@H:2]([CH3:20])[CH2:3][CH2:4][C:5]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:6]=1[NH3+:13]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 23434290HCID 23434290, compound

Product 1

HCID 69702667HCID 69702667, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of the the product from Step B (7.31 g, 2.29 mmol), ethanol (100 mL), concentrated HCl (50 mL) and water (30 mL) was heated at reflux for three days. The volatile material was removed by evaporation and the residue was dried overnight. The residue was triturated with ethyl acetate, filtered and dried under a vacuum to give an amorphous powder (4.11 g, 68%).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for three days
  3. customThe volatile material was removed by evaporation
  4. customthe residue was dried overnight
  5. customThe residue was triturated with ethyl acetate
  6. filtrationfiltered
  7. customdried under a vacuum

Sources & evidence

ORD record
ord-9b1f17d7df5240c1ad4150b61e22c110
Source dataset
uspto-grants-2004_02
Patent number
US06696476B2

Reaction notes

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