1-((S)-2-Azidopropyl)-1,7,8,9-tetrahydro-pyrano[2,3-g]indazol-8-ol → 1-((S)-2-Aminopropyl)-1,7,8,9-tetrahydro-pyrano[2,3-g]indazol-8-ol

HRID 2121887Notes

Reaction equation

HRID 2121887 reaction equation
[N:1]([C@@H:4]([CH3:20])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]3[O:18][CH2:17][CH:16]([OH:19])[CH2:15][C:13]3=2)[CH:8]=[N:7]1)=[N+]=[N-]>CO>[NH2:1][C@@H:4]([CH3:20])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]3[O:18][CH2:17][CH:16]([OH:19])[CH2:15][C:13]3=2)[CH:8]=[N:7]1

Participants

3

Reactant 1

HCID 867596521-((S)-2-Azidopropyl)-1,7,8,9-tetrahydro-pyrano[2,3-g]indazol-8-ol

Product 1

HCID 98347631-((S)-2-Aminopropyl)-1,7,8,9-tetrahydro-pyrano[2,3-g]indazol-8-olYield 88%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of the product from Step A in methanol was treated as described in Example 2, Step J to give the free base as an amorphous solid (0.36 g, 88%): mp 46-51° C.; GCMS(Cl+) m/z 248 (M+H). Analysis. Calculated for C13H17N3O2.0.1H2O: C, 62.68; H, 6.96; N, 16.97. Found: C, 62.55; H, 7.03; N, 16.64.

Sources & evidence

ORD record
ord-ac3ac85eed0d448594f6b393a655c64d
Source dataset
uspto-grants-2004_02
Patent number
US06696476B2

Reaction notes

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