Ethylamine → N-Ethyl-3-nitropyridin-4-amine

HRID 2121941Notes

Reaction equation

HRID 2121941 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[CH2:11]([NH2:13])[CH3:12]>>[CH2:11]([NH:13][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9])[CH3:12]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 27357814-Chloro-3-nitropyridine

Product 1

HCID 21937597N-Ethyl-3-nitropyridin-4-amine

Procedure

In a manner similar to example 31, the title compound was prepared from 4-chloro-3-nitropyridine, prepared according to published procedure [J. Med. Chem. 1996, 39, 487-493], and ethylamine. 1H-NMR (CDCl3): δ 9.22 (1H, s), 8.30 (1H, d), 8.10 (1H, br s), 6.71 (1H, d), 3.40 (2H, m), 1.39 (3H, t).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-4dd46c2879854acb83494dab66875f27
Source dataset
uspto-grants-2004_02
Patent number
US06696473B2

Reaction notes

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