Methyl p-toluenesulfonate → 2-Dimethylamino-N-{3-[3-furan-2-ylmethyl-5-(5-methoxy-3-methyl-3H-benzothiazol-2-ylidene)-4-oxothiazolidin-2-ylideneamino]-phenyl}acetamide
Reaction equation
S[C:2]1[S:3][C:4]2[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:5]=2[N:6]=1.[C:13]1(C)C=CC(S(OC)(=O)=O)=CC=1.[CH3:25][N:26]([CH3:50])[CH2:27][C:28]([NH:30][C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([N:37]=[C:38]2[N:42]([CH2:43][C:44]3[O:45][CH:46]=[CH:47][CH:48]=3)[C:41](=[O:49])[CH2:40][S:39]2)[CH:32]=1)=[O:29]>>[CH3:25][N:26]([CH3:50])[CH2:27][C:28]([NH:30][C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([N:37]=[C:38]2[N:42]([CH2:43][C:44]3[O:45][CH:46]=[CH:47][CH:48]=3)[C:41](=[O:49])[C:40](=[C:2]3[N:6]([CH3:13])[C:5]4[CH:7]=[C:8]([O:11][CH3:12])[CH:9]=[CH:10][C:4]=4[S:3]3)[S:39]2)[CH:32]=1)=[O:29]Participants
4
Procedure
In a manner similar to Example 45, 2-mercapto-5-methoxybenzothiazole was alkylated with methyl p-toluenesulfonate and then condensed with 2-dimethylamino-N-[3-(3-furan-2-ylmethyl-4-oxothiazolidin-2-ylideneamino)-phenyl]acetamide. MS(ESI): 550 (MH+).
Sources & evidence
- ORD record
- ord-f02f017d39e24fecb69b2c63d05e12a7
- Source dataset
- uspto-grants-2004_02
- Patent number
- US06696473B2
Reaction notes
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