Boron tribromide → HCID 73855076, compound

HRID 2121996Notes

Reaction equation

HRID 2121996 reaction equation
[CH2:1]([N:8]1[C:12](=[O:13])[C:11](=[C:14]2[N:18]([CH3:19])[C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[O:26]C)=[CH:16][S:15]2)[S:10][C:9]1=[N:28][C:29]1[CH:30]=[C:31]([CH:34]=[CH:35][C:36]=1[NH:37][CH2:38][CH3:39])[C:32]#[N:33])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.B(Br)(Br)Br>C(Cl)Cl>[CH2:1]([N:8]1[C:12](=[O:13])[C:11](=[C:14]2[N:18]([CH3:19])[C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[OH:26])=[CH:16][S:15]2)[S:10][C:9]1=[N:28][C:29]1[CH:30]=[C:31]([CH:34]=[CH:35][C:36]=1[NH:37][CH2:38][CH3:39])[C:32]#[N:33])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 73854985HCID 73854985, compound

Product 1

HCID 73855076HCID 73855076, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product of Example 192 was treated with boron tribromide in DCM at 25° C. After 15 min the product mixture was quenched with brine, concentrated and chromatographed (silica gel, 0-10% MeOH/DCM) to yield the title compound. MS(ESI): 540 (MH+).

Workup

  1. customAfter 15 min the product mixture was quenched with brine
  2. concentrationconcentrated
  3. customchromatographed (silica gel, 0-10% MeOH/DCM)

Sources & evidence

ORD record
ord-ac9ae3b9f75c493fbd9be3ce0a104424
Source dataset
uspto-grants-2004_02
Patent number
US06696473B2

Reaction notes

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