Acetophenone → Acetophenonoxime

HRID 2122101Notes

Reaction equation

HRID 2122101 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=O)[CH3:2].Cl.[NH2:11][OH:12]>N1C=CC=CC=1>[C:1](=[N:11][OH:12])([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:2]

Participants

4

Reactant 2

HCID 7410AcetophenoneHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 69185AcetophenonoximeYield 95%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In a 50 ml round-bottom flask, a mixture of acetophenone, hydroxylamine hydrochloride in pyridine was stirred, at room temperature under nitrogen blanket, for five days. The reaction mixture was then concentrated under vacuum to remove most of pyridine. The oil was then distilled at 55° C. under 0.1 mbar. The product was obtained in 95% yield.

Workup

  1. concentrationThe reaction mixture was then concentrated under vacuum
  2. customto remove most of pyridine
  3. distillationThe oil was then distilled at 55° C. under 0.1 mbar
  4. customThe product was obtained in 95% yield

Sources & evidence

ORD record
ord-f26c005abae64fe99b36cd44ff7ad7fa
Source dataset
uspto-grants-2004_02
Patent number
US06696608B1

Reaction notes

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