2-Octanone → 2-Octanone, oxime

HRID 2122102Notes

Reaction equation

HRID 2122102 reaction equation
[CH3:1][C:2](=O)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].Cl.[NH2:11][OH:12]>N1C=CC=CC=1>[CH3:1][C:2](=[N:11][OH:12])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

4

Reactant 2

HCID 80932-OctanoneHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 816282-Octanone, oximeYield 87%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In a 50 ml round-bottom flask, a mixture of 2-octanone, hydroxylamine hydrochloride in pyridine was stirred, at room temperature under nitrogen blanket, for five days. The reaction mixture was then concentrated under vacuum to remove most of pyridine. The oil was then dissolved in dichloromethane. The product precipitated on standing. The product was obtained as a white solid in 87% yield.

Workup

  1. concentrationThe reaction mixture was then concentrated under vacuum
  2. customto remove most of pyridine
  3. dissolutionThe oil was then dissolved in dichloromethane
  4. customThe product precipitated
  5. customThe product was obtained as a white solid in 87% yield

Sources & evidence

ORD record
ord-5bf78b06f3d2408f919fb86dce39417d
Source dataset
uspto-grants-2004_02
Patent number
US06696608B1

Reaction notes

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