Pyridine → HCID 23434938, compound

HRID 2122107Notes

Reaction equation

HRID 2122107 reaction equation
S(Cl)([Cl:3])=O.[Cl:5][C:6]([Cl:18])=[C:7]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)[C:8](O)=[O:9].N1C=CC=CC=1>C(OCC)C>[Cl:5][C:6]([Cl:18])=[C:7]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)[C:8]([Cl:3])=[O:9]

Participants

5

Reactant 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 441116HCID 441116, compound

Product 1

HCID 23434938HCID 23434938, compoundYield 78.4%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
22.5 °C

Procedure

35.5 g (0.298 mol) of thionyl chloride were added dropwise at 0° C. to the solution of 50 g (0.199 mol) of the acid of Example 4 in 200 ml of diethyl ether and 23.6 g (0.298 mol) of pyridine. The solution was stirred for 6 hours at 20 to 25° C. and then filtered. After the solvent had been distilled off, 42.1 g of the product were obtained, and this was reacted further without purification.

Workup

  1. filtrationfiltered
  2. distillationAfter the solvent had been distilled off

Sources & evidence

ORD record
ord-75e7ea7a7009443db6c122859115e526
Source dataset
uspto-grants-2004_02
Patent number
US06696607B2

Reaction notes

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