Dichloromethane → 2-(3-Cyclopropyl-5-(piperidin-4-ylidenemethyl)phenoxy)-5-(trifluoromethyl)pyridine

HRID 212296Notes

Reaction equation

HRID 212296 reaction equation
[CH:1]1([c:4]2[cH:5][c:6]([CH:7]=[C:8]3[CH2:9][CH2:10][N:11]([C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])[CH2:12][CH2:13]3)[cH:21][c:22]([O:24][c:25]3[n:26][cH:27][c:28]([C:31]([F:32])([F:33])[F:34])[cH:29][cH:30]3)[cH:23]2)[CH2:2][CH2:3]1.[Cl:42][CH2:43][Cl:44].[OH:35][C:36]([C:37]([F:38])([F:39])[F:40])=[O:41]>>[CH:1]1([c:4]2[cH:5][c:6]([CH:7]=[C:8]3[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]3)[cH:21][c:22]([O:24][c:25]3[n:26][cH:27][c:28]([C:31]([F:32])([F:33])[F:34])[cH:29][cH:30]3)[cH:23]2)[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66875428Tert-butyl 4-(3-cyclopropyl-5-(5-(trifluoromethyl)pyridin-2-yloxy)benzylidene)piperidine-1-carboxylate

Product 1

HCID 668754182-(3-Cyclopropyl-5-(piperidin-4-ylidenemethyl)phenoxy)-5-(trifluoromethyl)pyridine

Sources & evidence

ORD record
ord-35b5f9ac7a024498b185612418d07915
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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