Bromide ion → Tert-butyl 2-(2,5-difluoro-4-phenylmethoxybenzoyl)morpholine-4-carboxylate

HRID 2123816Notes

Reaction equation

HRID 2123816 reaction equation
[Br-:1].[C:28]([CH3:29])([CH3:30])([CH3:31])[O:32][C:33](=[O:34])[N:35]1[CH2:36][CH:37]([C:41]([N:42]([O:43][CH3:44])[CH3:45])=[O:46])[O:38][CH2:39][CH2:40]1.[CH2:11]([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[O:18][c:19]1[c:20]([F:27])[cH:21][c:22]([Br:26])[c:23]([F:25])[cH:24]1.[CH2:6]([Li:7])[CH2:8][CH2:9][CH3:10].[CH:2]([Mg+:3])([CH3:4])[CH3:5].[O:47]1[CH2:48][CH2:49][CH2:50][CH2:51]1.[OH2:52]>>[CH2:11]([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[O:18][c:19]1[c:20]([F:27])[cH:21][c:22]([C:41]([CH:37]2[CH2:36][N:35]([C:33]([O:32][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:34])[CH2:40][CH2:39][O:38]2)=[O:46])[c:23]([F:25])[cH:24]1

Participants

8

Reactant 7

HCID 259Bromide ionHCID 962WaterHCID 8028TetrahydrofuranHCID 57449675Tert-butyl 2-(methoxy(methyl)carbamoyl)morpholine-4-carboxylateHCID 580861601-Benzyloxy-4-bromo-2,5-difluorobenzeneHCID 178418339ButyllithiumHCID 178461726HCID 178461726, compound

Product 1

HCID 67073315Tert-butyl 2-(2,5-difluoro-4-phenylmethoxybenzoyl)morpholine-4-carboxylate

Sources & evidence

ORD record
ord-02be56778f4642c3be62a3233712abb5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

Loading…