Tetrahydrofuran → 1-Ethyl-4-(2-fluoro-3-(methylthio)phenyl)piperidin-4-ol
Reaction equation
[Br:1][c:2]1[c:3]([F:10])[c:4]([S:8][CH3:9])[cH:5][cH:6][cH:7]1.[CH2:11]([Li:12])[CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[CH2:18]([CH3:19])[N:20]1[CH2:21][CH2:22][C:23](=[O:26])[CH2:24][CH2:25]1.[O:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1>>[c:2]1([C:23]2([OH:26])[CH2:22][CH2:21][N:20]([CH2:18][CH3:19])[CH2:25][CH2:24]2)[c:3]([F:10])[c:4]([S:8][CH3:9])[cH:5][cH:6][cH:7]1Participants
5
Sources & evidence
- ORD record
- ord-846624542fe6417eb814315949b59423
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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