2-(Dimethylamino)ethanol → 2-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-N,N-dimethylethanamine

HRID 2124831Notes

Reaction equation

HRID 2124831 reaction equation
[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[CH3:19][N:20]([CH3:21])[CH2:22][CH2:23][OH:24].[Cl:1][c:2]1[n:3][c:4]([N:11]2[CH2:12][CH:13]3[CH2:14][CH2:15][CH:16]([CH2:17]2)[O:18]3)[c:5]2[c:6]([n:7]1)[nH:8][n:9][cH:10]2.[O:25]=[C:26]([O:27][CH:28]([CH3:29])[CH3:30])[N:31]=[N:32][C:33]([O:34][CH:35]([CH3:36])[CH3:37])=[O:38]>>[Cl:1][c:2]1[n:3][c:4]([N:11]2[CH2:12][CH:13]3[CH2:14][CH2:15][CH:16]([CH2:17]2)[O:18]3)[c:5]2[c:6]([n:7]1)[n:8]([CH2:23][CH2:22][N:20]([CH3:19])[CH3:21])[n:9][cH:10]2

Participants

5

Reactant 4

HCID 79022-(Dimethylamino)ethanolHCID 8028TetrahydrofuranHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 201118843-(6-chloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-8-oxa-3-azabicyclo[3.2.1]octane

Product 1

HCID 866293652-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-N,N-dimethylethanamine

Sources & evidence

ORD record
ord-cd954964811d4c17898bb7011743869b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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