Morpholine → 4-[5-(1,1-Dimethoxyethyl)-2-methoxy-3-trifluoromethylphenyl]morpholine

HRID 2125415Notes

Reaction equation

HRID 2125415 reaction equation
[Br:1][c:2]1[c:3]([O:18][CH3:19])[c:4]([C:14]([F:15])([F:16])[F:17])[cH:5][c:6]([C:8]([CH3:9])([O:10][CH3:11])[O:12][CH3:13])[cH:7]1.[C:20](=[O:21])([O-:22])[O-:23].[CH2:68]1[CH2:69][O:70][CH2:71][CH2:72][NH:73]1.[CH3:26][C:27]1([CH3:28])[c:29]2[cH:30][cH:31][cH:32][c:33]([P:34]([c:35]3[cH:36][cH:37][cH:38][cH:39][cH:40]3)[c:41]3[cH:42][cH:43][cH:44][cH:45][cH:46]3)[c:47]2[O:48][c:49]2[c:50]1[cH:51][cH:52][cH:53][c:54]2[P:55]([c:56]1[cH:57][cH:58][cH:59][cH:60][cH:61]1)[c:62]1[cH:63][cH:64][cH:65][cH:66][cH:67]1.[Cs+:24].[Cs+:25].[O:74]1[CH2:75][CH2:76][O:77][CH2:78][CH2:79]1>>[c:2]1([N:73]2[CH2:68][CH2:69][O:70][CH2:71][CH2:72]2)[c:3]([O:18][CH3:19])[c:4]([C:14]([F:15])([F:16])[F:17])[cH:5][c:6]([C:8]([CH3:9])([O:10][CH3:11])[O:12][CH3:13])[cH:7]1

Participants

7

Reactant 6

HCID 8083MorpholineHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 104967Cesium cation2×HCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)HCID 580856971-Bromo-5-(1,1-dimethoxyethyl)-2-methoxy-3-trifluoromethylbenzene

Product 1

HCID 580856994-[5-(1,1-Dimethoxyethyl)-2-methoxy-3-trifluoromethylphenyl]morpholine

Sources & evidence

ORD record
ord-4465be6a1ff940bbae19174f06d739dd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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