Methanol → 2-methyl-N-{8-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-dioxaspiro[4.5]dec-8-yl}propane-2-sulfinamide
Reaction equation
[CH3:58][OH:59].[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[Cl:65][CH2:66][Cl:67].[O:41]1[CH2:42][CH2:43][O:44][C:45]12[CH2:46][CH2:47][C:48](=[N:51][S:52](=[O:53])[C:54]([CH3:55])([CH3:56])[CH3:57])[CH2:49][CH2:50]2.[O:60]1[CH2:61][CH2:62][CH2:63][CH2:64]1.[OH:8][CH:9]1[C:10]([OH:11])([c:16]2[s:17][c:18](-[c:21]3[cH:22][c:23]([CH3:38])[cH:24][c:25]([NH:27][c:28]4[n:29][cH:30][cH:31][c:32]([C:34]([F:35])([F:36])[F:37])[n:33]4)[cH:26]3)[cH:19][n:20]2)[CH2:12][CH2:13][NH:14][C:15](=[O:39])[CH2:40]1>>[c:16]1([C:48]2([NH:51][S:52](=[O:53])[C:54]([CH3:55])([CH3:56])[CH3:57])[CH2:47][CH2:46][C:45]3([O:41][CH2:42][CH2:43][O:44]3)[CH2:50][CH2:49]2)[s:17][c:18](-[c:21]2[cH:22][c:23]([CH3:38])[cH:24][c:25]([NH:27][c:28]3[n:29][cH:30][cH:31][c:32]([C:34]([F:35])([F:36])[F:37])[n:33]3)[cH:26]2)[cH:19][n:20]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-4c34392f2e0449e8aa9beccff4be0fff
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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