Hydrochloric Acid → N-[2,4-difluoro-5-(4-piperidinyl)phenyl]-2-methylpropanamide

HRID 212729Notes

Reaction equation

HRID 212729 reaction equation
[CH2:29]1[O:30][CH2:31][CH2:32][O:33][CH2:34]1.[ClH:28].[F:1][c:2]1[c:3]([CH:15]2[CH2:16][CH2:17][N:18]([C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[CH2:19][CH2:20]2)[cH:4][c:5]([NH:9][C:10]([CH:11]([CH3:12])[CH3:13])=[O:14])[c:6]([F:8])[cH:7]1>>[F:1][c:2]1[c:3]([CH:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]2)[cH:4][c:5]([NH:9][C:10]([CH:11]([CH3:12])[CH3:13])=[O:14])[c:6]([F:8])[cH:7]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 16757165Tert-butyl 4-[2,4-difluoro-5-(isobutyrylamino)phenyl]-1-piperidinecarboxylate

Product 1

HCID 16757253N-[2,4-difluoro-5-(4-piperidinyl)phenyl]-2-methylpropanamide

Sources & evidence

ORD record
ord-466c11d8a01f483d953fac25ff28ce6e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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