Trifluoroacetic acid → N-(3-tert-Butyl-phenyl)-4-piperidin-4-yl-benzamide

HRID 212767Notes

Reaction equation

HRID 212767 reaction equation
[C:40]([c:41]1[cH:42][cH:43][c:44]([NH:45][C:46](=[O:47])[c:48]2[cH:49][cH:50][c:51]([N:52]3[CH2:53][CH2:54][NH:55][CH2:56][CH2:57]3)[n:58][cH:59]2)[cH:60][cH:61]1)([CH3:62])([CH3:63])[CH3:64].[C:8]([O:9][C:10](=[O:11])[N:15]1[CH2:16][CH2:17][CH:18]([c:21]2[cH:22][cH:23][c:24]([C:27]([NH:28][c:29]3[cH:30][c:31]([C:35]([CH3:36])([CH3:37])[CH3:38])[cH:32][cH:33][cH:34]3)=[O:39])[cH:25][cH:26]2)[CH2:19][CH2:20]1)([CH3:12])([CH3:13])[CH3:14].[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7]>>[NH:15]1[CH2:16][CH2:17][CH:18]([c:21]2[cH:22][cH:23][c:24]([C:27]([NH:28][c:29]3[cH:30][c:31]([C:35]([CH3:36])([CH3:37])[CH3:38])[cH:32][cH:33][cH:34]3)=[O:39])[cH:25][cH:26]2)[CH2:19][CH2:20]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 593180124-[4-(3-Tert-butyl-phenylcarbamoyl)-phenyl]-piperidine-1-carboxylic acid tert-butyl esterHCID 59318019N-(4-tert-Butyl-phenyl)-6-piperazin-1-yl-nicotinamide

Product 1

HCID 59317976N-(3-tert-Butyl-phenyl)-4-piperidin-4-yl-benzamide

Sources & evidence

ORD record
ord-d268f8dcdaf54dbaae7ca0db495c2c86
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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