Hydrochloric Acid → (4,4-Difluoro-piperidin-1-yl)-[5-hydroxy-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-methanone

HRID 212770Notes

Reaction equation

HRID 212770 reaction equation
[ClH:24].[F:25][C:26]1([F:32])[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]1.[OH:1][c:2]1[cH:3][c:4]2[cH:5][c:6]([C:16](=[O:17])[N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[n:7]([CH2:11][C:12]([F:13])([F:14])[F:15])[c:8]2[cH:9][cH:10]1>>[OH:1][c:2]1[cH:3][c:4]2[cH:5][c:6]([C:16](=[O:17])[N:18]3[CH2:19][CH2:20][C:26]([F:25])([F:32])[CH2:22][CH2:23]3)[n:7]([CH2:11][C:12]([F:13])([F:14])[F:15])[c:8]2[cH:9][cH:10]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 27583524,4-DifluoropiperidineHCID 67527268[5-Hydroxy-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-morpholin-4-yl-methanone

Product 1

HCID 67526963(4,4-Difluoro-piperidin-1-yl)-[5-hydroxy-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-methanone

Sources & evidence

ORD record
ord-d68315cee74549f480b708f44f0a2495
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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