Hydrochloric Acid → 5-(7-Methyl-4-morpholino-6-(piperazin-1-ylmethyl)thieno[3,2-d]pyrimidin-2-yl)-4-(trifluoromethyl)pyrimidin-2-amine

HRID 2127774Notes

Reaction equation

HRID 2127774 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][N:11]([CH2:14][c:15]2[c:16]([CH3:41])[c:17]3[n:18][c:19](-[c:30]4[c:31]([C:37]([F:38])([F:39])[F:40])[n:32][c:33]([NH2:36])[n:34][cH:35]4)[n:20][c:21]([N:24]4[CH2:25][CH2:26][O:27][CH2:28][CH2:29]4)[c:22]3[s:23]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH2:43]1[O:44][CH2:45][CH2:46][O:47][CH2:48]1.[ClH:42]>>[NH:8]1[CH2:9][CH2:10][N:11]([CH2:14][c:15]2[c:16]([CH3:41])[c:17]3[n:18][c:19](-[c:30]4[c:31]([C:37]([F:38])([F:39])[F:40])[n:32][c:33]([NH2:36])[n:34][cH:35]4)[n:20][c:21]([N:24]4[CH2:25][CH2:26][O:27][CH2:28][CH2:29]4)[c:22]3[s:23]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 669342684-[2-(2-Amino-4-trifluoromethyl-pyrimidin-5-yl)-7-methyl-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 582339795-(7-Methyl-4-morpholino-6-(piperazin-1-ylmethyl)thieno[3,2-d]pyrimidin-2-yl)-4-(trifluoromethyl)pyrimidin-2-amine

Sources & evidence

ORD record
ord-d50dc68198c94b8fafff6962509e115c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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