Hydrochloric Acid → 4-(3,5-Difluoro-phenoxy)-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide

HRID 2128019Notes

Reaction equation

HRID 2128019 reaction equation
[ClH:22].[ClH:23].[ClH:24].[F:1][c:2]1[cH:3][c:4]([O:5][c:6]2[c:7]3[cH:8][c:9]([C:15](=[O:16])[OH:17])[nH:10][c:11]3[cH:12][cH:13][cH:14]2)[cH:18][c:19]([F:21])[cH:20]1.[NH2:25][CH:26]1[CH2:27][CH2:28][N:29]([CH2:32][CH2:33][N:34]2[CH2:35][CH2:36][CH:37]([OH:40])[CH2:38][CH2:39]2)[CH2:30][CH2:31]1>>[F:1][c:2]1[cH:3][c:4]([O:5][c:6]2[c:7]3[cH:8][c:9]([C:15](=[O:17])[NH:25][CH:26]4[CH2:27][CH2:28][N:29]([CH2:32][CH2:33][N:34]5[CH2:35][CH2:36][CH:37]([OH:40])[CH2:38][CH2:39]5)[CH2:30][CH2:31]4)[nH:10][c:11]3[cH:12][cH:13][cH:14]2)[cH:18][c:19]([F:21])[cH:20]1

Participants

4

Reactant 3

HCID 313Hydrochloric Acid3×HCID 596002201-[2-(4-Aminopiperidin-1-yl)ethyl]piperidin-4-olHCID 668416404-(3,5-difluoro-phenoxy)-1H-indole-2-carboxylic acid

Product 1

HCID 596002274-(3,5-Difluoro-phenoxy)-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide

Sources & evidence

ORD record
ord-4ad9498b4a9541a38d694b5e545776d4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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