Tetrahydrofuran → 2-Chloro-N-(6-(8-(2,2,2-trifluoroacetyl)-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1H-inden-1-yl)benzamide

HRID 212809Notes

Reaction equation

HRID 212809 reaction equation
[CH2:63]1[O:64][CH2:65][CH2:66][CH2:67]1.[Cl:1][c:2]1[c:3]([C:4](=[O:5])[NH:6][CH:7]2[CH2:8][CH2:9][c:10]3[cH:11][cH:12][c:13]([C:16](=[O:17])[OH:18])[cH:14][c:15]32)[cH:19][cH:20][cH:21][cH:22]1.[F:47][C:48]([C:49](=[O:50])[N:51]1[CH2:52][CH2:53][C:54]2([CH2:55][CH2:56][NH:57][CH2:58]2)[CH2:59][CH2:60]1)([F:61])[F:62].[P-:23]([F:24])([F:25])([F:26])([F:27])([F:28])[F:29].[n:30]1([O:31][C:32]([N:33]([CH3:34])[CH3:35])=[N+:36]([CH3:37])[CH3:38])[c:39]2[n:40][cH:41][cH:42][cH:43][c:44]2[n:45][n:46]1>>[Cl:1][c:2]1[c:3]([C:4](=[O:5])[NH:6][CH:7]2[CH2:8][CH2:9][c:10]3[cH:11][cH:12][c:13]([C:16](=[O:18])[N:57]4[CH2:56][CH2:55][C:54]5([CH2:53][CH2:52][N:51]([C:49]([C:48]([F:47])([F:61])[F:62])=[O:50])[CH2:60][CH2:59]5)[CH2:58]4)[cH:14][c:15]32)[cH:19][cH:20][cH:21][cH:22]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 9886HexafluorophosphateHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 595052323-[(2-chloro-benzoyl)amino]-2,3-dihydro-1H-indene-5-carboxylic acidHCID 595052392,2,2-Trifluoro-1-(2,8-diazaspiro[4.5]decan-8-yl)ethanone

Product 1

HCID 595057192-Chloro-N-(6-(8-(2,2,2-trifluoroacetyl)-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1H-inden-1-yl)benzamide

Sources & evidence

ORD record
ord-c788a1b23adf4729883c75f03576b62f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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