Dichloromethane → 1-(3-Chloropyridin-2-yl)piperazine

HRID 2128465Notes

Reaction equation

HRID 2128465 reaction equation
[Cl:1][c:2]1[c:3]([N:8]2[CH2:9][CH2:10][N:11]([C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])[CH2:12][CH2:13]2)[n:4][cH:5][cH:6][cH:7]1.[Cl:28][CH:29]([Cl:30])[CH3:31].[Cl:32][CH2:33][Cl:34].[F:21][C:22]([F:23])([F:24])[C:25]([OH:26])=[O:27]>>[Cl:1][c:2]1[c:3]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[n:4][cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 63651,1-DichloroethaneHCID 6422Trifluoroacetic acidHCID 11630777Tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate

Product 1

HCID 114129441-(3-Chloropyridin-2-yl)piperazine

Sources & evidence

ORD record
ord-a71aa22105ba4220a1695a05f037a4b8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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