Tetrahydrofuran → 5-{[3-(Tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-hydroxy-methyl}-2-chloro-benzenesulfonamide

HRID 2128507Notes

Reaction equation

HRID 2128507 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([O:16][CH3:17])[c:6]([O:7][Si:8]([CH3:9])([CH3:10])[C:11]([CH3:12])([CH3:13])[CH3:14])[cH:15]1.[C:18]([Li:19])([CH3:20])([CH3:21])[CH3:22].[Cl:23][c:24]1[c:25]([S:32](=[O:33])(=[O:34])[NH2:35])[cH:26][c:27]([CH:30]=[O:31])[cH:28][cH:29]1.[O:36]1[CH2:37][CH2:38][CH2:39][CH2:40]1>>[c:2]1([CH:30]([c:27]2[cH:26][c:25]([S:32](=[O:33])(=[O:34])[NH2:35])[c:24]([Cl:23])[cH:29][cH:28]2)[OH:31])[cH:3][cH:4][c:5]([O:16][CH3:17])[c:6]([O:7][Si:8]([CH3:9])([CH3:10])[C:11]([CH3:12])([CH3:13])[CH3:14])[cH:15]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 109800492-(T-Butyldimethylsilyloxy)-4-bromoanisoleHCID 146546022-Chloro-5-formylbenzene-1-sulfonamideHCID 178418306HCID 178418306, compound

Product 1

HCID 581074595-{[3-(Tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-hydroxy-methyl}-2-chloro-benzenesulfonamide

Sources & evidence

ORD record
ord-7d916cf9cae64257841a55e5038942ec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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