1,2-Dimethoxyethane → 6-(4-Bromo-2-fluorophenyl)-3-pyridinol

HRID 2129110Notes

Reaction equation

HRID 2129110 reaction equation
[Br:1][c:2]1[n:3][cH:4][c:5]([OH:8])[cH:6][cH:7]1.[Br:9][c:10]1[cH:11][c:12]([F:19])[c:13]([B:16]([OH:17])[OH:18])[cH:14][cH:15]1.[CH3:20][O:21][CH2:22][CH2:23][O:24][CH3:25].[Pd:26]([Cl:27])[Cl:28].[c:29]1([P:30]([c:31]2[cH:32][cH:33][cH:34][cH:35][cH:36]2)[c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[cH:43][cH:44][cH:45][cH:46][cH:47]1.[c:48]1([P:49]([c:50]2[cH:51][cH:52][cH:53][cH:54][cH:55]2)[c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)[cH:62][cH:63][cH:64][cH:65][cH:66]1>>[c:2]1(-[c:13]2[c:12]([F:19])[cH:11][c:10]([Br:9])[cH:15][cH:14]2)[n:3][cH:4][c:5]([OH:8])[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 80711,2-DimethoxyethaneHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 27628652-Bromo-5-hydroxypyridineHCID 27733334-Bromo-2-fluorobenzeneboronic acid

Product 1

HCID 666732076-(4-Bromo-2-fluorophenyl)-3-pyridinol

Sources & evidence

ORD record
ord-ac6fd31f86324495ac32d0753326efb4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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