Dimethylformamide → 3,6-Difluoro-2-[7-(6-morpholin-4-yl-pyridin-3-yl)-3,4-dihydro-2H-pyrido[2,3-b]pyrazin-1-ylmethyl]benzonitrile

HRID 2130098Notes

Reaction equation

HRID 2130098 reaction equation
[Cl:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:11][cH:12][c:13](-[c:15]4[cH:16][n:17][c:18]([N:21]5[CH2:22][CH2:23][O:24][CH2:25][CH2:26]5)[cH:19][cH:20]4)[cH:14]3)[NH:8][CH2:9][CH2:10]2)[c:27]([F:32])[cH:28][cH:29][c:30]1[F:31].[Cu:33][C:34]#[N:35].[O:36]=[CH:37][N:38]([CH3:39])[CH3:40]>>[c:2]1([C:34]#[N:35])[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:11][cH:12][c:13](-[c:15]4[cH:16][n:17][c:18]([N:21]5[CH2:22][CH2:23][O:24][CH2:25][CH2:26]5)[cH:19][cH:20]4)[cH:14]3)[NH:8][CH2:9][CH2:10]2)[c:27]([F:32])[cH:28][cH:29][c:30]1[F:31]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 578861351-(2-Chloro-3,6-difluorobenzyl)-7-(6-morpholin-4-yl-pyridin-3-yl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazineHCID 178418546HCID 178418546, compound

Product 1

HCID 578860773,6-Difluoro-2-[7-(6-morpholin-4-yl-pyridin-3-yl)-3,4-dihydro-2H-pyrido[2,3-b]pyrazin-1-ylmethyl]benzonitrile

Sources & evidence

ORD record
ord-91cac6ac49d840e2a1fb4ca918a6d4bb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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