Dichloromethane → 1-(1,3-benzodioxol-5-yl)-N-[5-[(S)-(2-chlorophenyl)[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]-2-thiazolyl]cyclopropanecarboxamide

HRID 2130170Notes

Reaction equation

HRID 2130170 reaction equation
[CH3:30][CH2:31][N:32]([CH2:33][CH3:34])[CH2:35][CH3:36].[CH3:37][S:38](=[O:39])(=[O:40])[Cl:41].[Cl:1][c:2]1[c:3]([CH:8]([c:9]2[cH:10][n:11][c:12]([NH:14][C:15](=[O:16])[C:17]3([c:20]4[cH:21][c:22]5[c:23]([cH:27][cH:28]4)[O:24][CH2:25][O:26]5)[CH2:18][CH2:19]3)[s:13]2)[OH:29])[cH:4][cH:5][cH:6][cH:7]1.[Cl:48][CH2:49][Cl:50].[NH:42]1[CH2:43][CH:44]([OH:47])[CH2:45][CH2:46]1>>[Cl:1][c:2]1[c:3]([CH:8]([c:9]2[cH:10][n:11][c:12]([NH:14][C:15](=[O:16])[C:17]3([c:20]4[cH:21][c:22]5[c:23]([cH:27][cH:28]4)[O:24][CH2:25][O:26]5)[CH2:18][CH2:19]3)[s:13]2)[N:42]2[CH2:43][CH:44]([OH:47])[CH2:45][CH2:46]2)[cH:4][cH:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 982104-HydroxypyrrolidineHCID 11774705HCID 11774705, compound

Product 1

HCID 534402641-(1,3-benzodioxol-5-yl)-N-[5-[(S)-(2-chlorophenyl)[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]-2-thiazolyl]cyclopropanecarboxamide

Sources & evidence

ORD record
ord-acc127f48cc74a1589e2a334ab34cc6d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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