Ethanol → 4-Methyl-2-{6-[2-(4-trifluoromethyl-phenyl)-ethyl]-pyrazin-2-yl}-thiazole-5-carboxylic acid benzylamide

HRID 2130312Notes

Reaction equation

HRID 2130312 reaction equation
[C:38]([O:39][CH2:40][CH3:41])(=[O:42])[CH3:43].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[NH:8][C:9](=[O:10])[c:11]1[c:12]([CH3:34])[n:13][c:14](-[c:16]2[n:17][c:18]([CH:22]=[CH:23][c:24]3[cH:25][cH:26][c:27]([C:30]([F:31])([F:32])[F:33])[cH:28][cH:29]3)[cH:19][n:20][cH:21]2)[s:15]1.[CH2:35]([OH:36])[CH3:37].[OH-:44].[OH-:45].[Pd+2:46]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[NH:8][C:9](=[O:10])[c:11]1[c:12]([CH3:34])[n:13][c:14](-[c:16]2[n:17][c:18]([CH2:22][CH2:23][c:24]3[cH:25][cH:26][c:27]([C:30]([F:31])([F:32])[F:33])[cH:28][cH:29]3)[cH:19][n:20][cH:21]2)[s:15]1

Participants

6

Reactant 5

HCID 702EthanolHCID 961Hydroxide2×HCID 8857Ethyl AcetateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 68491515HCID 68491515, compound

Product 1

HCID 249547004-Methyl-2-{6-[2-(4-trifluoromethyl-phenyl)-ethyl]-pyrazin-2-yl}-thiazole-5-carboxylic acid benzylamide

Sources & evidence

ORD record
ord-c5b4b77e6dc74a43bff943b61966a65f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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