(6-(3-Methylisothiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methanamine → 4-(8-((6-(3,5-Difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methylamino)-1,5-naphthyridin-3-yl)piperidin-4-ol
Reaction equation
[CH3:44][c:45]1[cH:46][c:47](-[c:48]2[cH:49][cH:50][c:51]3[n:52]([c:53]([CH2:54][NH2:55])[n:56][n:57]3)[n:58]2)[s:59][n:60]1.[F:1][c:2]1[cH:3][c:4](-[c:9]2[cH:10][cH:11][c:12]3[n:13]([n:14]2)[c:15]([CH2:18][NH:19][c:20]2[cH:21][cH:22][n:23][c:24]4[cH:25][c:26]([C:30]5([OH:43])[CH2:31][CH2:32][N:33]([C:36]([O:37][C:38]([CH3:39])([CH3:40])[CH3:41])=[O:42])[CH2:34][CH2:35]5)[cH:27][n:28][c:29]24)[n:16][n:17]3)[cH:5][c:6]([F:8])[cH:7]1>>[F:1][c:2]1[cH:3][c:4](-[c:9]2[cH:10][cH:11][c:12]3[n:13]([n:14]2)[c:15]([CH2:18][NH:19][c:20]2[cH:21][cH:22][n:23][c:24]4[cH:25][c:26]([C:30]5([OH:43])[CH2:31][CH2:32][NH:33][CH2:34][CH2:35]5)[cH:27][n:28][c:29]24)[n:16][n:17]3)[cH:5][c:6]([F:8])[cH:7]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-299f8746a49e4b9098d8e295b6bda4d2
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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