Dichloromethane → N-[4-[2-[3-(5-chloro-2-hydroxyphenyl)-1-(2-hydroxyethyl)pyrazol-4-yl]ethynyl]phenyl]piperidine-2-carboxamide
Reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH:9]([C:14]([NH:15][c:16]2[cH:17][cH:18][c:19]([C:22]#[C:23][c:24]3[c:25](-[c:32]4[c:33]([OH:39])[cH:34][cH:35][c:36]([Cl:38])[cH:37]4)[n:26][n:27]([CH2:29][CH2:30][OH:31])[cH:28]3)[cH:20][cH:21]2)=[O:40])[CH2:10][CH2:11][CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:48][CH2:49][Cl:50].[F:41][C:42]([F:43])([F:44])[C:45]([OH:46])=[O:47]>>[NH:8]1[CH:9]([C:14]([NH:15][c:16]2[cH:17][cH:18][c:19]([C:22]#[C:23][c:24]3[c:25](-[c:32]4[c:33]([OH:39])[cH:34][cH:35][c:36]([Cl:38])[cH:37]4)[n:26][n:27]([CH2:29][CH2:30][OH:31])[cH:28]3)[cH:20][cH:21]2)=[O:40])[CH2:10][CH2:11][CH2:12][CH2:13]1Participants
4
Sources & evidence
- ORD record
- ord-0cf2d054ca6d4748bd56d1517b9bbd25
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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