Hydrochloric Acid → 5-amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

HRID 213121Notes

Reaction equation

HRID 213121 reaction equation
[CH3:31][OH:32].[ClH:28].[NH2:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[CH2:7][C:6]1([CH2:5]2)[C:11](=[O:27])[N:12]([CH2:19][O:20][CH2:21][CH2:22][Si:23]([CH3:24])([CH3:25])[CH3:26])[c:13]2[n:14][cH:15][cH:16][cH:17][c:18]21.[Na+:30].[OH-:29].[OH2:33]>>[NH2:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[CH2:7][C:6]1([CH2:5]2)[C:11](=[O:27])[NH:12][c:13]2[n:14][cH:15][cH:16][cH:17][c:18]21

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 591667205-amino-1'-((2-(trimethylsilyl)ethoxy)methyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Product 1

HCID 591667225-amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Sources & evidence

ORD record
ord-9ef29c234cea426aab2635dacf9ae8b1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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