Dichloromethane → Trifluoroacetic acid

HRID 2131313Notes

Reaction equation

HRID 2131313 reaction equation
[Cl:33][CH2:34][Cl:35].[F:26][C:27]([C:28](=[O:29])[OH:30])([F:31])[F:32].[O:1]=[C:2]1[N:3]([CH:13]2[CH2:14][CH2:15][N:16]([C:19]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[CH2:17][CH2:18]2)[CH2:4][CH2:5][c:6]2[c:7]([cH:9][cH:10][cH:11][cH:12]2)[NH:8]1>>[F:26][C:27]([C:28](=[O:29])[OH:30])([F:31])[F:32].[O:1]=[C:2]1[N:3]([CH:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)[CH2:4][CH2:5][c:6]2[c:7]([cH:9][cH:10][cH:11][cH:12]2)[NH:8]1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 58823744Tert-butyl 4-(2-oxo-1,2,4,5-tetrahydrobenzo[d][1,3]diazepin-3-yl)piperidine-1-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 113795873-(Piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-one

Sources & evidence

ORD record
ord-9e6f6c5823ac4ef793e924be5752d70b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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