Dichloromethane → 5-nitro-N4-piperidin-4-ylmethyl-N2-(2-trifluoromethoxy-benzyl)-pyridine-2,4-diamine

HRID 2131904Notes

Reaction equation

HRID 2131904 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][NH:15][c:16]2[cH:17][c:18]([NH:25][CH2:26][c:27]3[c:28]([O:33][C:34]([F:35])([F:36])[F:37])[cH:29][cH:30][cH:31][cH:32]3)[n:19][cH:20][c:21]2[N+:22](=[O:23])[O-:24])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:45][CH2:46][Cl:47].[F:38][C:39]([F:40])([F:41])[C:42]([OH:43])=[O:44]>>[NH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][NH:15][c:16]2[cH:17][c:18]([NH:25][CH2:26][c:27]3[c:28]([O:33][C:34]([F:35])([F:36])[F:37])[cH:29][cH:30][cH:31][cH:32]3)[n:19][cH:20][c:21]2[N+:22](=[O:23])[O-:24])[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 587126844-{[5-Nitro-2-(2-trifluoromethoxy-benzylamino)-pyridin-4-ylamino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 119512495-nitro-N4-piperidin-4-ylmethyl-N2-(2-trifluoromethoxy-benzyl)-pyridine-2,4-diamine

Sources & evidence

ORD record
ord-3dfbb09dd7f04502b3cf13c9f8aa9b92
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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