Tetrahydrofuran → 6-chloro-4-hydroxy-4-phenyl-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one
Reaction equation
[C:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)(=[O:8])[c:9]1[c:10]([NH:16][C:17](=[O:18])[n:19]2[cH:20][cH:21][n:22][cH:23]2)[cH:11][cH:12][c:13]([Cl:15])[cH:14]1.[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[F:24][C:25]([CH2:26][NH2:27])([F:28])[F:29]>>[C:1]1([c:2]2[cH:3][cH:4][cH:5][cH:6][cH:7]2)([OH:8])[c:9]2[c:10]([cH:11][cH:12][c:13]([Cl:15])[cH:14]2)[NH:16][C:17](=[O:18])[N:27]1[CH2:26][C:25]([F:24])([F:28])[F:29]Participants
4
Sources & evidence
- ORD record
- ord-0406c4277e4544d49ca4e626b0cdeb2f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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