Hydrochloric Acid → N-(3-chloro-4-(piperazin-1-yl)phenyl)picolinamide

HRID 2133248Notes

Reaction equation

HRID 2133248 reaction equation
[Cl:37][CH2:38][Cl:39].[Cl:8][c:9]1[c:10]([N:24]2[CH2:25][CH2:26][N:27]([C:30]([O:31][C:32]([CH3:33])([CH3:34])[CH3:35])=[O:36])[CH2:28][CH2:29]2)[cH:11][cH:12][c:13]([NH:15][C:16]([c:17]2[n:18][cH:19][cH:20][cH:21][cH:22]2)=[O:23])[cH:14]1.[ClH:1].[O:2]1[CH2:3][CH2:4][O:5][CH2:6][CH2:7]1>>[Cl:8][c:9]1[c:10]([N:24]2[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]2)[cH:11][cH:12][c:13]([NH:15][C:16]([c:17]2[n:18][cH:19][cH:20][cH:21][cH:22]2)=[O:23])[cH:14]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 312751,4-DioxaneHCID 67441071Tert-butyl 4-(2-chloro-4-(picolinamido)phenyl)piperazine-1-carboxylate

Product 1

HCID 67441344N-(3-chloro-4-(piperazin-1-yl)phenyl)picolinamide

Sources & evidence

ORD record
ord-c8dc6cb2f7c64ad78047fe12049a291c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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