Dichloromethane → 2-amino-N-[1-[4-benzyl-4-(dimethylaminocarbamoyl)piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide

HRID 213409Notes

Reaction equation

HRID 213409 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][C:8]([CH3:9])([CH3:10])[C:11]([NH:12][CH:13]([C:14](=[O:15])[N:16]1[CH2:17][CH2:18][C:19]([C:22](=[O:23])[NH:24][N:25]([CH3:26])[CH3:27])([CH2:28][c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[CH2:20][CH2:21]1)[CH2:35][c:36]1[cH:37][nH:38][c:39]2[cH:40][cH:41][cH:42][cH:43][c:44]12)=[O:45])([CH3:5])([CH3:6])[CH3:46].[CH2:54]([Cl:55])[Cl:56].[OH:47][C:48]([C:49]([F:50])([F:51])[F:52])=[O:53]>>[NH2:7][C:8]([CH3:9])([CH3:10])[C:11]([NH:12][CH:13]([C:14](=[O:15])[N:16]1[CH2:17][CH2:18][C:19]([C:22](=[O:23])[NH:24][N:25]([CH3:26])[CH3:27])([CH2:28][c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[CH2:20][CH2:21]1)[CH2:35][c:36]1[cH:37][nH:38][c:39]2[cH:40][cH:41][cH:42][cH:43][c:44]12)=[O:45]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 69019306(1-(2-(4-benzyl-4-(N',N'-dimethylhydrazinocarbonyl)piperidine-1-yl)-1-(1H-indol-3-ylmethyl)-2-oxoethylcarbamoyl)-1-methylethyl)carbamic acid tert-butyl ester

Product 1

HCID 183651912-amino-N-[1-[4-benzyl-4-(dimethylaminocarbamoyl)piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide

Sources & evidence

ORD record
ord-2d269de33384459d99f73d9ec16c8f35
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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