Tetrahydrofuran → (1-benzenesulfonyl-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-methanol

HRID 2134415Notes

Reaction equation

HRID 2134415 reaction equation
[CH2:21]([Li:22])[CH2:23][CH2:24][CH3:25].[CH3:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31].[CH3:32][S:33][c:34]1[c:35]([C:42]([F:43])([F:44])[F:45])[cH:36][c:37]([CH:38]=[O:39])[cH:40][cH:41]1.[O:46]1[CH2:47][CH2:48][CH2:49][CH2:50]1.[c:1]1([S:7](=[O:8])(=[O:9])[n:10]2[cH:11][cH:12][c:13]3[c:14]2[n:15][cH:16][c:17]([O:19][CH3:20])[cH:18]3)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([S:7](=[O:8])(=[O:9])[n:10]2[c:11]([CH:38]([c:37]3[cH:36][c:35]([C:42]([F:43])([F:44])[F:45])[c:34]([S:33][CH3:32])[cH:41][cH:40]3)[OH:39])[cH:12][c:13]3[c:14]2[n:15][cH:16][c:17]([O:19][CH3:20])[cH:18]3)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8058HexaneHCID 222736501H-Pyrrolo[2,3-B]pyridine, 5-methoxy-1-(phenylsulfonyl)-HCID 59234010Benzaldehyde, 4-(methylthio)-3-(trifluoromethyl)-HCID 178418339Butyllithium

Product 1

HCID 67229413(1-benzenesulfonyl-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-methanol

Sources & evidence

ORD record
ord-813ef9ffae414e10a4bec0148d31baff
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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