Tetrahydrofuran → (1-methyl-cyclopropyl)-[5-triisopropylsilanyl-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-methanone

HRID 2134871Notes

Reaction equation

HRID 2134871 reaction equation
[CH3:33][CH2:34][CH2:35][CH2:36][Li:37].[CH3:38][O:39][N:40]([C:41](=[O:42])[C:43]1([CH3:46])[CH2:44][CH2:45]1)[CH3:47].[I:1][c:2]1[cH:3][n:4]([Si:23]([CH:24]([CH3:25])[CH3:26])([CH:27]([CH3:28])[CH3:29])[CH:30]([CH3:31])[CH3:32])[c:5]2[n:6][cH:7][c:8](-[c:11]3[cH:12][c:13]([O:21][CH3:22])[c:14]([O:19][CH3:20])[c:15]([O:17][CH3:18])[cH:16]3)[n:9][c:10]12.[O:48]1[CH2:49][CH2:50][CH2:51][CH2:52]1>>[c:2]1([C:41](=[O:42])[C:43]2([CH3:46])[CH2:44][CH2:45]2)[cH:3][n:4]([Si:23]([CH:24]([CH3:25])[CH3:26])([CH:27]([CH3:28])[CH3:29])[CH:30]([CH3:31])[CH3:32])[c:5]2[n:6][cH:7][c:8](-[c:11]3[cH:12][c:13]([O:21][CH3:22])[c:14]([O:19][CH3:20])[c:15]([O:17][CH3:18])[cH:16]3)[n:9][c:10]12

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 45084195HCID 45084195, compoundHCID 595405257-iodo-5-triisopropylsilanyl-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazineHCID 178418339Butyllithium

Product 1

HCID 67342981(1-methyl-cyclopropyl)-[5-triisopropylsilanyl-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-methanone

Sources & evidence

ORD record
ord-ca204ce2b2a84aa3813af8c82e5a0afa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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