反应详情

Next, the 3-fluoro-4-methoxybenzoic acid (IV) was digested with HBr (20 ml) and glacial acetic acid (40 ml) overnight. Most of the acetic acid was distilled off and the remaining mixture was diluted with water. The precipitated benzoic acid was extracted in ether; the ether layer was dried, filtered and rotary evaporated to produce 11.0 g of the 3-fluoro-4-hydroxybenzoic acid (V).

1. distillationMost of the acetic acid was distilled off
2. additionthe remaining mixture was diluted with water
3. extractionThe precipitated benzoic acid was extracted in ether
4. dry with materialthe ether layer was dried
5. filtrationfiltered
6. customrotary evaporated