Bromide ion → 3-Chloro-6-(2,6-difluorobenzyl)pyridazine

HRID 213538Notes

Reaction equation

HRID 213538 reaction equation
[Br-:9].[CH2:20]1[O:21][CH2:22][CH2:23][CH2:24]1.[Cl:1][c:2]1[n:3][n:4][c:5]([Cl:8])[cH:6][cH:7]1.[F:10][c:11]1[c:12]([CH2:13][Zn+:14])[c:15]([F:19])[cH:16][cH:17][cH:18]1.[cH:25]1[cH:26][cH:27][c:28]([P:29]([Pd:30]([P:31]([c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)([c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)[c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)([P:50]([c:51]2[cH:52][cH:53][cH:54][cH:55][cH:56]2)([c:57]2[cH:58][cH:59][cH:60][cH:61][cH:62]2)[c:63]2[cH:64][cH:65][cH:66][cH:67][cH:68]2)[P:69]([c:70]2[cH:71][cH:72][cH:73][cH:74][cH:75]2)([c:76]2[cH:77][cH:78][cH:79][cH:80][cH:81]2)[c:82]2[cH:83][cH:84][cH:85][cH:86][cH:87]2)([c:88]2[cH:89][cH:90][cH:91][cH:92][cH:93]2)[c:94]2[cH:95][cH:96][cH:97][cH:98][cH:99]2)[cH:100][cH:101]1>>[Cl:1][c:2]1[n:3][n:4][c:5]([CH2:13][c:12]2[c:11]([F:10])[cH:18][cH:17][cH:16][c:15]2[F:19])[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 259Bromide ionHCID 8028TetrahydrofuranHCID 673313,6-DichloropyridazineHCID 178420554HCID 178420554, compoundHCID 178505727HCID 178505727, compound

Product 1

HCID 575312393-Chloro-6-(2,6-difluorobenzyl)pyridazine

Sources & evidence

ORD record
ord-11a503423a464a368fe0fa1123d24480
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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