Bicarbonate Ion → tert-butyl 3-[[1-(4-methoxybutyl)benzimidazole-2-carbonyl]-methylamino]-5-(morpholine-4-carbonyl)piperidine-1-carboxylate

HRID 2135611Notes

Reaction equation

HRID 2135611 reaction equation
[C:49](=[O:50])([OH:51])[O-:52].[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][n:7]1[c:8]([C:16](=[O:17])[NH:18][CH:19]2[CH2:20][N:21]([C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[CH2:22][CH:23]([C:25](=[O:26])[N:27]3[CH2:28][CH2:29][O:30][CH2:31][CH2:32]3)[CH2:24]2)[n:9][c:10]2[c:11]1[cH:12][cH:13][cH:14][cH:15]2.[CH3:42][I:43].[H-:40].[Na+:41].[Na+:53].[O:44]=[CH:45][N:46]([CH3:47])[CH3:48]>>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][n:7]1[c:8]([C:16](=[O:17])[N:18]([CH:19]2[CH2:20][N:21]([C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[CH2:22][CH:23]([C:25](=[O:26])[N:27]3[CH2:28][CH2:29][O:30][CH2:31][CH2:32]3)[CH2:24]2)[CH3:42])[n:9][c:10]2[c:11]1[cH:12][cH:13][cH:14][cH:15]2

Participants

7

Reactant 6

HCID 769Bicarbonate IonHCID 923Sodium ion2×HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 166653HydrideHCID 178495020HCID 178495020, compound

Product 1

HCID 178495021tert-butyl 3-[[1-(4-methoxybutyl)benzimidazole-2-carbonyl]-methylamino]-5-(morpholine-4-carbonyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-ad7b0f685bdf48b7b6d2b8d221bf6126
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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